Autoantibodies against matrix metalloproteinase-1 in patients with localized scleroderma

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Autoantibodies against matrix metalloproteinase-1 in patients with localized scleroderma.

BACKGROUND Localized scleroderma (LSc) is characterized by cutaneous fibrosis and various autoantibodies. OBJECTIVE To determine the presence or levels of antibodies (Abs) against matrix metalloproteinase (MMP)-1 and their clinical relevance in LSc. METHODS Anti-MMP-1 Ab was examined by ELISA (Enzyme-Linked ImmunoSorbent Assay) and immunoblotting using human recombinant MMP-1. MMP-1 collage...

متن کامل

Autoantibodies against PDGF receptor in scleroderma.

n engl j med 354;25 www.nejm.org june 22, 2006 2709 Tashkin DP, Elashoff R, Clements PJ, et al. Cyclophosphamide versus placebo in scleroderma lung disease. N Engl J Med 2006;354:2655-66. Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J 2005;26:948-68. Bouros D, Wells AU, Nicholson AG, et al. Histopathologic subsets of fibrosing alveoliti...

متن کامل

Autoantibodies in childhood scleroderma.

The clinical presentation of scleroderma in childhood is even more varied than in adult life. This study of 19 children shows that antinuclear antibodies (ANA) detected on the HEp2 cell substrate are just as common as in the adult disorders. All seven children with diffuse scleroderma or acrosclerosis were ANA positive, as were eight of the 12 with more localised disease. Antinucleolar antibodi...

متن کامل

Anti-phosphatidylserine-prothrombin complex antibodies in patients with localized scleroderma.

OBJECTIVE Although some antiphospholipid antibodies (Abs) are found in patients with localized scleroderma (LSc), Ab against phosphatidylserine-prothrombin complex (PS/PT) has not been examined. We investigated anti-PS/PT Ab levels in patients with LSc. METHODS IgG anti-PS/PT Ab levels in serum samples taken from patients with LSc (n = 42) were measured using ELISA. RESULTS IgG anti-PS/PT A...

متن کامل

Primary localized cutaneous amyloidosis in patients with scleroderma.

Primary localized cutaneous amyloidosis (PLCA) is a relatively rare condition characterized by amyloid de-position exclusively in the dermis without involving the internal organs. Clinically, papular, macular and tumefac-tive forms are presented. Although PLCA may sometimes overlap with collagen vascular diseases, association with scleroderma is rare. We report here two cases of PLCA developing...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Dermatological Science

سال: 2008

ISSN: 0923-1811

DOI: 10.1016/j.jdermsci.2008.04.013